Specific and selective If inhibition: expected clinical benefits from pure heart rate reduction in coronary patients
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چکیده
منابع مشابه
the role of type-d personality, social support and self-compassion in prediction of health behaviors in coronary heart disease patients
نظر به اهمیت و تاثیر روزافزون عوامل روانی – اجتماعی در سلامت جسمی و تاثیر عوامل روان شناختی در بروز بیماریهای مختلف از جمله بیماریهای قلبی و عروقی این پژوهش با هدف کلی بررسی ارتباط تیپ شخصیتی d ، حمایت اجتماعی و خود دلسوزی در پیش بینی رفتارهای بهداشتی بیماران کرونر قلبی و تعیین تفاوت بین بیماران کرونر قلبی با و بدون جراحی و افراد سالم در این متغیرها و رفتارهای بهداشتی آنان، انجام گرفت. جامعه آ...
15 صفحه اولSelective and Specific Inhibition of If with Ivabradine for the Treatment of Coronary Artery Disease or Heart Failure
Heart rate is an important contributor in the pathophysiology of both coronary artery disease (CAD) and heart failure (HF). Ivabradine is an anti-anginal and anti-ischaemic agent, which selectively and specifically inhibits the I f current in the sino-atrial node and provides pure heart rate reduction without altering other cardiac parameters, including conduction, and without directly affectin...
متن کاملHeart-rate reduction by If-channel inhibition with ivabradine restores collateral artery growth in hypercholesterolemic atherosclerosis.
AIMS Collateral arteries protect tissue from ischaemia. Heart rate correlates with vascular events in patients with arterial obstructive disease. Here, we tested the effect of heart-rate reduction (HRR) on collateral artery growth. METHODS AND RESULTS The I(f)-channel inhibitor ivabradine reduced heart rate by 11% in wild-type and 15% in apolipoprotein E (ApoE)(-/-) mice and restored endothel...
متن کاملEffect of long-term heart rate reduction by If current inhibition on pressure overload-induced heart failure in rats.
We investigated the effects of long-term heart rate reduction (HRR) on pressure overload-induced heart failure. Pressure overload of the left ventricle was induced in 21-day-old rats by banding the ascending aorta. HRR was induced for 3 months with ivabradine (n = 44), a selective I(f) current inhibitor, at 10 mg/kg/day, starting 14 days after banding. Thirty-six control banded rats and 16 sham...
متن کاملClinical Update If Current and Heart Rate Control
Understanding the mechanisms underlying the spontaneous depolarization of cardiac cell membranes, either those of the sinoatrial node or those that may have this ability, such as Purkinje fiber cells in the His bundle, has always been important, because it is the spontaneous depolarization during phase 4 of the action potential that allows these cells to determine a heartbeat, that is to say, a...
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ژورنال
عنوان ژورنال: European Heart Journal Supplements
سال: 2005
ISSN: 1554-2815,1520-1554
DOI: 10.1093/eurheartj/sui048